SUN-609 Livoletide (AZP-531), an Unacylated Ghrelin Analogue, Improves Hyperphagia and Food-Related Behaviors Both in Obese and Non-Obese People with Prader-Willi Syndrome
نویسندگان
چکیده
منابع مشابه
AZP-531, an unacylated ghrelin analog, improves food-related behavior in patients with Prader-Willi syndrome: A randomized placebo-controlled trial
CONTEXT AND OBJECTIVE Prader-Willi syndrome (PWS) is characterized by early-onset hyperphagia and increased circulating levels of the orexigenic Acylated Ghrelin (AG) hormone with a relative deficit of Unacylated Ghrelin (UAG). AZP-531, a first-in-class UAG analog, was shown to inhibit the orexigenic effect of AG in animals, to improve glycemic control and decrease body weight in humans. We aim...
متن کاملMedication Trials for Hyperphagia and Food-Related Behaviors in Prader–Willi Syndrome
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by the absence of paternally expressed, imprinted genes on chromosome 15q11-13. Individuals with PWS characteristically have poor feeding and lack of appetite in infancy, followed by the development of weight gain and then uncontrolled appetite and lack of satiety, sometime after the age of two. The overwhelming drive to eat is...
متن کاملAn obese female with Prader-Willi syndrome and daytime sleepiness.
A obese 13-year-old female with Prader-Willi syndrome (PWS) was referred for evaluation of excessive daytime sleepiness. She was a resident of a group home for persons with PWS allowing for dietary management and a regimented schedule. Her daily wake time was 06:30 and bedtime was 21:00. The patient had a tonsillectomy and adenoidectomy at age 5 years for obstructive sleep apnea and had never b...
متن کاملElevated ratio of acylated to unacylated ghrelin in children and young adults with Prader–Willi syndrome
Prader-Willi syndrome (PWS) is characterized by a switch from failure to thrive to excessive weight gain and hyperphagia in early childhood. Hyperghrelinemia may be involved in the underlying mechanisms of the switch. The purpose of this study is to evaluate acylated ghrelin (AG) and unacylated ghrelin (UAG) levels in PWS and investigate their associations with hyperphagia. This is a cross-sect...
متن کاملAssessment of hyperphagia in Prader-Willi syndrome.
OBJECTIVE Prader-Willi syndrome (PWS), the leading known genetic cause of obesity, is characterized by intellectual disabilities, maladaptive and compulsive behaviors, and hyperphagia. Although complications of obesity resulting from hyperphagia are the leading cause of death in PWS, quantifying this drive for food has long been an unmet research need. This study provides factor-analytic and wi...
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2020
ISSN: 2472-1972
DOI: 10.1210/jendso/bvaa046.1004